Helps reduce the unpleasant feeling caused by , tobacco or overeating.Advancis® Refresh is a combination of silymarin, vitamin C, B-complex vitamins and caffeine. These ingredients have detox and revitalizing action, thus helps reduce the unpleasant feeling caused by alcohol, tobacco or overeating. Silymarin: promotes the relief of “hangover” symptoms like headaches, dehydration, muscle pain and have Hepatoprotective, detox and digestive properties. Vitamin C Contributes to the protection of cells against undesirable oxidation and to the reduction of tiredness and fatigue. Vitamins B2 and B6 Contribute to the energy-producing metabolism Caffeine Stimulant reduces fatigue and increases mental alertness.